原 著：《Cancer Immunology》译 著：《肿瘤免疫学》

This book focusing on the immunopathology of cancers is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Readers will find detailed descriptions of the interactions between cancerous cells and various components of the innate and adaptive immune system. The principal focus, however, is very much on clinical aspects, the aim being to educate clinicians in the clinical implications of the latest research and novel developments in the field.

In the new edition of this very well received book, first published in 2015, the original chapters have been significantly updated and additional chapters included on, for example, current knowledge on the roles of T-helper cells and NK cells in tumor immunity, the part played by oncoviruses in the development of various cancers, and the applications of fluorescent in situ hybridization, bioluminescence, and cancer molecular and functional imaging. Cancer Immunology: A Translational Medicine Context will be of special value to clinical immunologists, hematologists, and oncologists.

1. Introduction on Cancer Immunology and Immunotherapy

2. Role of Innate Immunity in Cancers and Antitumor Response 

3. Tumor-Associated Myeloid Cells in Cancer Progression 

4. B-Cells in Cancer Immunology: For or Against Cancer Growth? 

5. The Roles of CD4+ T-Cells in Tumor Immunity 

6. Regulatory T-Cells and Th17 Cells in Tumor Microenvironment 

7. T-Cell Metabolism and Its Dysfunction Induced by Cancer 

8. The Role of Exhaustion in Tumor-Induced T-Cell Dysfunction in Cancer  

9. The Role of NK Cells in Cancer 

10. Role of Plasmacytoid Dendritic Cells in Cancer 

11. The CD95/CD95L Signaling Pathway: A Role in Carcinogenesis 

12. MHC Class I Molecules and Cancer Progression: Lessons Learned from Preclinical Mouse Models 

13. Role of Cytokines in Tumor Immunity and Immune Tolerance to Cancer 

14. Role of Chemokines and Chemokine Receptors in Cancer 

15. Role of the Inflammasome in Cancer 

16. Cancer Immunoediting: Immunosurveillance, Immune Equilibrium, and Immune Escape 

17. Apoptosis and Cancer 

18. Endoplasmic Reticulum Stress and Autophagy in Cancer 

19. Prognostic Value of Innate and Adaptive Immunity in Cancers 

20. Immunogenetics of Cancer 

21. Epigenetics and MicroRNAs in Cancer 

22. The Role of DNA Methylation in CancerImmunosenescence, Oxidative Stress, and Cancers 

23. Immunosenescence, Oxidative Stress, and Cancers

24. Nutrition, Immunity, and Cancers

25. Inborn Errors of Immunity and Cancers 

26. Allergies and Cancers 

27. Envisioning the Application of Systems Biology in Cancer Immunology 

28. Principles of Immunological Diagnostic Tests for Cancers 

29. Immunohistochemistry of Cancers 

30. Fluorescent In Situ Hybridization: Methods and Application in Cancer Diagnosis 

31. Cancer Molecular and Functional Imaging 

32. Cancer Imaging with Radiolabeled Monoclonal Antibodies 

33. Flow Cytometry in Cancer Immunotherapy: Applications, Quality Assurance, and Future